To our knowledge, this is the second case report of granulomatous
Allopurinol is metabolized to oxypurinol which is also an inhibitor of xanthine oxidase; allopurinol acts on purine catabolism, reducing the production of uric acid without disrupting the biosynthesis Allopurinol therapy was started, 100 mg twice daily
As you can see, the major effect of the allopurinol is disrupting the liver
The majority of the 11 patients with allopurinol related liver injury in the current study had evidence of a hypersensitivity reaction and jaundice when they presented
Low white blood cell counts (leukopenia) Bone marrow suppression
Infrequently, patients can present with liver injury characterized by acute cholestatic hepatitis
Descriptions
No abnormalities in liver function test were attributed to allopurinol treatment
Allopurinol reduces levels of uric acid in the blood and urine
Understanding liver function tests: part 2