However, the genotoxicity of rabeprazole sodium and its impurities is still unclear
Based on mass spectral data vide LC-MS, the two impurities were characterized as 2-{[(4-chloro-3-methyl-2-pyridinyl) methyl] sulfinyl}-1H-bezimidazole (2, chloro analogue of
Based on the complete spectral analysis (, Mass and IR), this new impurity was designated as 2- [ [ (3-methyl-4- (methylthio)-2-pyridinyl)methyl]sulfinyl]-1
Six impurities in rabeprazole sodium bulk drug substance were detected by a simple isocratic high performance chromatographic method (HPLC) whose
Abstract Rabeprazole sodium [1] is a proton pump inhibitor, used as an antiulcerative
A minimal list of stress factors suggested for forced degradation studies must include acid and base hydrolysis, thermal degradation, photolysis, oxidation [5], [14], [15], [16] and may include freeze–thaw cycles and shear [10]
05-0
Rabeprazole sodium is not official in any Standards of rabeprazole and the potential genotoxic impurities CPAR and FBCI were obtained from TLC Pharmaceutical Standards (Ontario, Canada)
Purity
Rabeprazole EP Impurity C can be used to generate other small molecule compounds, which is suitable for the related studies of proton pump regulation and
It is known to be an acid-labile drug, however, few data about its stability under other factors are available
J Pharm Biomed Anal
In the presence of both impurities and degradation products resulting from decomposition of rabeprazole, Buchireddy et al
}, author={Ganta Madhusudhan Reddy and B Vijaya
LC-MS was performed to identify the mass of the impurities
3 It is also a potential impurity in commercial preparations of rabeprazole
0,C14H10N3O3 : Na Identification and characterization of stressed degradation products of rabeprazole using LC-ESI/MS/MS and 1H-NMR
Excessive adsorption not only makes the drug impurity attain the protection, but also reduces the sonocatalytic activity of TiO 2 because of mutual screens among the TiO 2 particles [16]